MAHAAMRUT: Human Placental Extract A Protective Shield From Our Mother.


According to WHO, the placenta as a human tissue is a pathological as well as hazardous health-care waste that must be handled carefully.  Soon after birth, it becomes serious medical waste capable of harboring and transmitting viral particles, and bacteria. It could become a good culture medium for these organisms if not disposed of properly, hence, a potential health and environmental hazard.
The placenta plays a key role in supplying oxygen and nutrients, eliminating waste products, and providing  strong endocrine support for pregnancy through hormonal secretions and immunological functions that protect the developing embryo.
This project aims at converting this biomedical waste product into life saving source by proper preservation and processing of the human placenta to isolate peptides, hormones, antibodies and most important of them all stem cells.
The placental extract serves as a source of protein and hormones and contains several biologically active substances that exert anti-oxidation, anti-inflammatory, immunomodulatory ( Changing the body's immune system by activating or suppressing its functions) and delayed aging effects.
The human placental extract is a natural medicine with great therapeutic potential for liver diseases, including Hepatitis, liver fibrosis, and fatty liver. It also promotes liver regeneration. 
As said before, stem cells can be isolated from the placenta. Well, what are stem cells?
Stem cells are cells that have the potential to develop into any other kind of cells, tissues, or organs in our body.
Stem cell transplants are used to treat leukemia,  as new stem cells restore the body's ability to produce healthy blood cells.
Stem cells help repair damaged tissues and organs and help replace cells damaged by chemotherapy. 
They can treat cancer by replacing bone marrow cells damaged by cancer or cancer treatments.
They don't have any specific shape,  structure or function. They are very versatile. They are very versatile. They can even be converted into nerve cells.They are the Big B for our body.
They can be used to research the cause of genetic defects, how diseases occur, and why certain cells develop into cancer cells? They can be used to test new drugs for safety and effectiveness. 
Stem cells can also be sourced from dental tooth pulp, umbilical cord blood, cord tissue as well as bone marrow.
There are also proofs of organs being successfully generated from stem cells-
(1)In 2001, Christine Mummery  and her team created beating heart cells outside the body.
(2)Pulmonary ionocytes, a newly discovered airway epithelial cell type affected the most by cystic fibrosis( It affects the cells producing sweat, mucus, and digestive juices .It causes these fluids to thicken and get sticky thus they plug up our tunes, ducts and passageways.) Can be developed by stem cells.
(3) In Japan Ophthalmologist Koshi Nishida and his colleagues at Osaka University have successfully used stem cells to treat corneal damage and restore vision.
And many more
In 2012 Noble Prize in physiology and medicine was awarded to stem cell pioneers Sir John Gurdon and Shinya Yamanaka for their discovery that mature cells can be reprogrammed  to pluripotent stem cells(Stem cells that can develop into most or all cell types in body )
"EVERY CELL IN OUR BODY HAS THE POTENTIAL TO CONVERT INTO STEM CELLS"
To preserve the placenta the steps are-
(1)Dissection of Umbilical cord, Wharton's jelly, Cord placenta Junction, Fetal  Placenta
(2)Mincing and partial digestion 
(3)Explant culturing (removing and culturing living cells or tissues from an organism outside of its body)
(4)Isolation and characterization
           Morphological evaluation of cells by light microscopy.
           Analysis of MSC(Mesenchymal stem cells) markers by flowcytometry(analysis of cells as they flow past lasers suspended in buffered salt based solution)
            Analysis of Pluripotency markers by Quantitative Reverse Transcription Polymerase Chain Reaction.
              Then multi-lineage differentiation (cells differentiate into multiple cells)
(5)Amplification and Potential Applications in Biotechnology,  Pharmaceuticals, Cell Therapy, Regenerative Medicine, Tissue Engineering  etc.
And in this way the placenta keeps protecting us as a protective shield from our mother.
     
-Saikedelics 🦋              



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